[Peripheral neuropathies with monoclonal gammopathy of undetermined significance]

ABSTRACT

The association of peripheral neuropathy and the monoclonal gammopathy of undetermined significance CMGUSD has been frequently reported in 8 to 36% of cases. While the neuropathy associated with IgM-MGUS is well characterized and is often associated with a reactivity of the monoclonal protein with neural antigens, the relationship between the neuropathy and IgG and IgA MGUS is less clear. We report two cases of sensitive-motor chronic poly neuropathies associated with IgG MGUS in the first, and IgM MGUS in the second. Their clinical symptoms are foot numbness, paresthesias, imbalance, and gait ataxia, progress about months. Treatment associate plasma exchange, corticosteroids in combination with immunosuppressant. neuropathies with IgM MGUS tend to be most refractory than IgG MGUS