[Prognostic factors of pneumococcal meningitis. Retrospective study of 31 cases]

ABSTRACT

Our aim was to study the susceptibility of Streptococcus pneumoniae to antibiotics in patients with pneumococcal meningitis and to search for the prognosis factors in those patients. We have studied retrospectively 31 cases of pneumococcal meningitis. Comparisons were performed with univariate analysis. The mean age was 36,7 +/- 20,5 years [ranged 9 and 78 years]. The sex ratio was 3,4. The susceptibility of Streptococcus pneumoniae to penicillin G was affected in 10 cases [33% of isolated pneumococcus. The MIC to penicillin G was >/= 2 in only one case. The hospital mortality was 26% [8/31]. With univariate analysis, factors associated with death were age >/= 55 years [Ss p= 0,006, OR 17.2; IC[95%] 2.3-134], albuminorachie >/= 7g/l [p= 0,002, OR 22; IC[95%] 1,9-251], shock [p= 0,031, OR 6.7; IC[95%], 1.05-42] and Glasgow Coma Score [GCS] penicillin G is not associated with a worse outcome in patients with pneumococcal meningitis. An age 55 years, albuminorachie >/= 7g/l shock and Glasgow Coma Score prognosis in our study