Spectrum of micro-organisms and anti-microbial resistance of gram negative micro-organisms in the intensive care unit at King Hussein Hospital

ABSTRACT

To determine the spectrum of micro-organisms and anti-microbial resistance of gram negative micro-organisms. A retrospective review was conducted at the Intensive Care Unit at King Hussein Medical Hospital between Jan 2007 and Jan 2008. Blood was withdrawn from every Intensive Care Unit patient suspected infection 48 hours post admission. Gram negative micro-organisms and antimicrobial resistance were determined by using the standard method at Prince Iman and Research Laboratory Center. A total of 610 blood culture specimens were obtained from 400 patients. Bacteria were isolated from 213 of these specimens. The different types of bacteria isolated were as follows 47% were coagulase negative staphylococcus epidermidis, 35% were gram negative bacteria and 5% were Candida. Among the gram negative isolate the most common was Acinetobacter baumannii 31% while the least common was Citrobacter and Morganella 1.4% each. Rates of anti-microbial susceptibility for Acinetobacter were 45% for Ciprofloxacillin, 39% for Amikacin and 30% for Imipenem and Piperacillin while 48% of the Acinetobacter isolate were multi-resistant. This study provides information on spectrum of micro-organisms and antibiotic resistance of blood isolates. It may be a useful and baseline guide for physicians initiating empiric therapy and may help in providing antibiotic therapy policy in our hospital