Angiotensin-converting enzyme insertion/deletion gene polymorphism in general population of west Azarbaijan, Iran

ABSTRACT

Angiotensin-converting enzyme [ACE] gene polymorphisms have been studied in different ethnic populations. We assessed the ACE gene insertion/deletion alleles frequencies and genotype distributions in a group of individuals from among the general population of west Azarbaijan, Iran, in order to determine the prevalence of deletion/deletion [D/D], deletion/insertion [D/I] and insertion/insertion [I/I] genotypes. In a cross-sectional study, 167 healthy individuals were enrolled in a randomized fashion. They were selected from the general population of west Azerbaijan, Iran. Polymerase chain reaction was carried out to determine the ACE D/D, D/I and I/I genotypes. The ACE alleles were D and I in 59.7% and 40.3% of the women, 59.3% and 40.7% of the men and 59.6% and 40.4% of all of the participants, respectively. The D/D, D/I, and I/I genotypes were observed in 22 [40.7%], 20 [37%], and 12 [22.2%] men, 41 [36.3%], 53 [46.9%], and 19 [16.8%] women, and 63 [37.7%], 73 [43.7%], and 31 [18.6%] participants, respectively. Statistical analysis showed that differences in ACE D and I alleles and genotype frequencies were not significant between the men and the women. In this study on the general population of west Azarbaijan, the frequencies of the ACE D and I alleles were 59.6% and 40.4%. The ACE D/D, D/I and I/I genotypes were seen in 37.7%, 43.7%, and 18.6% of the studied population, respectively