Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein[a] in maintenance hemodialysis patients on statin therapy
IJKD-Iranian Journal of Kidney Diseases. 2011; 5 (2): 114-118
en Inglés
| IMEMR
| ID: emr-109876
ABSTRACT
Dyslipidemia and high serum lipoprotein[a] are among the risk factors for cardiovascular diseases in hemodialysis patients. Statins as a first line of therapy in hyperlipidemia does not always reduce the serum lipoprotein[a] level. Several studies have reported the lipid-lowering effects of carnitine and coenzyme Q10 in hemodialysis patients. This study was designed to investigate the effects of carnitine and coenzyme Q10 on serum lipid profile and lipoprotein[a] level in maintenance hemodialysis patients. This was a randomized placebo-controlled trial. We studied on hemodialysis patients who were on treatment with atorvastatin or lovastatin to assess the efficacy of supplement therapy. They were divided into 4 groups to receive carnitine, coenzyme Q10, both carnitine and coenzyme Q10, and placebo. After a 3-month experiment, blood samples were collected to measure serum levels of lipoprotein[a], triglyceride, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. Fifty-two hemodialysis patients, 27 men and 25 women, completed the course of the study. Three months after supplement therapy, serum levels of lipoprotein[a] reduced significantly in the carnitine, coenzyme Q10, and combination groups compared to the baseline values and the 3-month value of lipoprotein[a] in the placebo group [P = .01]. Serum levels of triglyceride and other lipoproteins did not significantly alter. Our study showed that supplementation with carnitine and coenzyme Q10 could reduce serum levels of lipoprotein[a] in maintenance hemodialysis patients treated with statins
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Placebos
/
Carnitina
/
Método Doble Ciego
/
Diálisis Renal
/
Ubiquinona
/
Resultado del Tratamiento
/
Coenzimas
/
Lípidos
/
Hipolipemiantes
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Iran. J. Kidney Dis.
Año:
2011
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