Polyherbal formulation development for hepatoprotective activity

ABSTRACT

Traditional system of medicine recommends various hepatoprotective agents and preparations to treat hepatic disorders. Polyherbal formulations F[1] [Crude drugs formulation], F[2] [Lab extracts formulation] and F[3] [commercial extracts formulation] were developed by using well documented medicinal plants, Cassia fistula, Coccinia indica and Vigna mungo for the treatment of liver disorders by exploiting the knowledge of Tradition system of medicine and evaluated for hepatoprotective activity using parameters including Alanine Transferase [ALAT], Aspartic Amino Transferase [ASAT], Alkaline phosphatase [ALP] and Total Proteins [TP]. Among these formulations F[2] and F[3] showed significant hepatoprotective activity at dose of 500 mg/kg, p.o., when compared to the CCI[4] control group II. Formulations F[2] and F[3] are effective against experimental liver damage. Biochemical parameters showed better results in lab extracts formulations