Cytotoxicity of cold ceramic compared with MTA and IRM
IEJ-Iranian Endodontic Journal. 2009; 4 (3): 106-111
en Inglés
| IMEMR
| ID: emr-110622
ABSTRACT
Biocompatibility is a desirable feature for root-end filling materials. In this study we aimed to compare a new material called cold ceramic [CC] with intermediate restorative material [IRM] and mineral trioxide aggregate [MTA] using Methyl-tetrazolium bromide [MTT] assay. The materials were tested in fresh and set states [n=108]. The cytotoxicity was compared using L929 fibroblasts as an indicator; tested materials were eluted with culture medium according to ISO 109935 standard. Distilled water and culture medium served as positive and negative controls, respectively [n=36]. The results were evaluated at 1, 24 hours and 7 days. Data were statistically analyzed by one-way ANOVA for each time interval and material status and t-tests. The cytotoxicity of the tested materials were statistically different at the various time intervals [P<0.001]. IRM was the most cytotoxic root-end filling material [P<0.001], MTA demonstrated the least cytotoxicity followed by CC. Despite displaying the greatest cytotoxicity, IRM is approved by the American Food and Drug Administration [PDA]. Cold ceramic had significantly lower cytotoxicity compared to IRM, in all but one subgroup. Further investigations are required to assess the clinical applicability of this novel material:
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Óxidos
/
Cerámica
/
Silicatos
/
Compuestos de Calcio
/
Compuestos de Aluminio
/
Restauración Dental Permanente
/
Combinación de Medicamentos
/
Fibroblastos
Idioma:
Inglés
Revista:
Iran. Endodontic J.
Año:
2009
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