effect of proton pump inhibitors on post endoscopic variceal band ligation complications

ABSTRACT

The study was done to evaluate the effect of proton pump inhibitors on the complications of variceal band ligation [EVL] and ulcer formation. It was conducted on 46 patients with esophageal varices [EV] asking for secondary prevention. Patients were randomly classified into group I of 22 patients received PPI [pantoprazole 40 mg] and group II of 24 patients received Placebo. Band ligation was done to all patients. Patients contacted after one week to assess for complications and adverse reactions. They re-endoscoped after 2 weeks and at that time the size and number of formed ulcer, chest pain and dysphagia all were assessed. EVL has a greater efficacy and fewer side effects for eradication of large EV with decrease in size and extent of varices. Post band ligation ulcer formation is of low incidence and risk. There is no significant difference in the number [1315] or the size of the formed ulcer [4.8mm5.6mm] between the two groups. The post band ligation rebleeding were more in group II than group I. Band ligation has no harmful effect on fundal varices or congestive gastropathy. Post band ligation administration of PPI has no significant effect on post band ulcer formation but associated with low risk of rebleeding