[In vitro antimicrobial drug-resistance of urinary tract pathogens in patients admitted to Vali-E-Asr Hospital Wards]

ABSTRACT

Extensive use of antibiotics in medicine has led to resistance of microorganisms in urinary tract infection [UTI] in both children and adults. Therefore, conducting studies on antibiotic susceptibility is needed for selection of antibiotics based on regional studies. During the year 2006 urine samples from all symptomatic patients admitted to neonatal, pediatrics, obstetric and neurologic wards were collected through midstream clean-catch, catheterization, or urine bags. An antibiogram test was performed for all 118 urine samples which were culture positive. The most common organisms found in neonatal urine culture were klebsiella pneumoniae [44/5%] followed by Escherichia coli [33/5%]. Escherichia coli was the most common organism in pediatrics [41%], obstetric [46%], and neurologic wards [73%]. Resistance to ampicillin [82/6%] and cefixime [73/6%] was significant in all samples. Ciprofloxacine was the most effective drug against E.coli and klebsiella pneumoniae in all wards [resistance rate 24/1%] followed by nitrofurantoin [resistance rate 41/4%], ceftriaxone [resistance rate 44/8%] and amikacin [resistance rate 51/9%]. Vancomycin was the most effective drug against staphylococcus epidermidis [resistance rate 37/1%] followed by cephtasidim [resistance rate 40/1%] and ciprofloxacine [resistance rate 48/5%]. Unfortunately due to irrational use of antibiotics, high resistance to ampicillin, cefixim, gentamycin, cotrimoxazol, and some other drugs was observed. Continuous studies regarding the drug resistance are recommended for better assessment in the future