Synthesis and evaluation of activity of some novel enaminones derived from poly [4-Hydroxy quinoline 2 [1H]-one Co acrylic acid] against murine schistosomiasis mansoni

ABSTRACT

In this work, hydrogels based on different ratios of acrylic acid [AAc] and 4-hydroxy quinaline 2 [IH]-one [BDHQ] monomers; were prepared by copolymerization using gamma-rays of [60]Co gamma cell as source. The hydrogels were characterized by versatile techniques. The effect of time absorption, pHs level, temperature, and ionic strength on the absorbency [%] of P [AAc/BDHQ] hydrogels were studied. In the application the prepared hydrogel samples to murine schistosomiasis mansoni field. The results revealed that the percentage of worm's reduction was 56.82% in case of PAAc or comp. I and 69.38% in case of P [AAc/BDHQ] or comp. II. The dead ova were recorded in comp. I and in comp. II were 45.5 +/- 1.11 and 50.25 +/- 1.17, respectively comparing to the control group. Also, It was observed that the Oogram patterns, curative dose of PZQ had Lethal effect on the mature eggs with 100% reduction