Serum level of lactate dehydrogenase, homocystein, hemoglobin and platelet in preeclampsia

ABSTRACT

Pre-eclampsia affects approximately 5-8% of pregnant women. The aim of this study was to compare the serum level of Lactate dehydrogenase [LDH], Homocystein, Hemoglubin and platelet in pregnant women diagnosed as pre-eclampsia and a normal group in Gorgan city, Northeastern Iran from 2007-2008. In this case control study, 50 cases of pre-eclampsia were compared with the control group women hospitalized in Dezyani hospital. Pre-eclampsia criteria were Blood pressure more than or equal to 140/ 90 mm hg and Proteinuria greater or equal to 300 mg/ 24 hours urine sample in the third trimester. Hemoglobin, platelet, LDH and hemocystein were measured. Data were analyzed by the mean of SPSS-14 program and Chi-2 or t-student were used. The difference of BMI and family incomes was significant between two groups [P-value<0.01]. LDH level was not statistically different between healthy and pre-eclamptic individuals. Six cases [12%] in controls and 9 cases [18%] in pre-eclamptic group had thrombocytopenia [P-value>0.01]. Hemocystein level was more than normal range in five patients with pre-eclampsia [P-value<0.001]. In this study, hemocystein level was significantly higher in pre-eclampsia patients but LDH, hemoglobin and platelet level had no significant difference