Efficacy of short-duration Furazolidone in two different quadruple regimens for H. pylori eradication

ABSTRACT

To assess the efficacy and tolerability of using high dose Furazolidone just during the first week of two different quadruple regimens in eradicating H. pylori. One-hundred sixty patients with duodenal ulcer and positive H. pylori infection were randomly allocated into two groups. Group A received [OAM-F] omeprazole [20 mg BID], amoxicillin [1gr BID], metronidazole [500mg BID] for two weeks and Furazolidone [200 mg BID] just during the first week. Patients in group B received [OAB-F] omeprazole [20 mg BID], amoxicillin [1 gr BID], bismuth subcitrate [240 mg BID] for two weeks and Furazolidone [200 mg BID] in the first week. The eradication rates by per-protocol and intention-to-treat analyses were 86.36% and 80% in group A and 90.27% and 86.3% in group B, respectively. Severe side effects of the drugs were more prevalent in group A compared with group B [12.8% against 2.5%]. One-week Furazolidone combined with two-week Omeprazole, amoxicillin and bismuth subcitrate is a safe and cost effective regimen to eradicate of H pylori infection in Iran