Treatment of cyclic thrombocytopenia with medroxy-progesterone acetate

ABSTRACT

A female with severe cyclic thrombocytopenia is reported. The periods of oscillation were between 21 to 31 days. The lowest platelet counts were at the time of ovulation when the estradiol secretion reaches a peak. The highest platelet counts were before menstrual flow when plasma progesterone is high. With the possibility that estrogen is the cause of thrombocytopenia and progesterone can counteract this effect, the patient was administered medroxy-progesterone acetate 10 mg per day, which resulted in correction of the periodic thrombocytopenia