Experimental infection of mice by naegleria fowleri or acanthamoeba culbertsoni isolated from water sites in Egypt

ABSTRACT

Naegleria fowleri and A. culbertsoni, which are known to cause primary amoebic meningoencephalitis [PAM] were isolated from water sites in Egypt. Each species was tested for pathogenicity in young mice, which were inoculated intracerebrally with amoebae. Mice developed illness and showed signs of menigo encephalitis followed by coma and death within 5 days. The histopathological finding in the brain sections of these animals revealed the same observations as in acute PAM of previous studies. These results proved that N. fowleri and A. culbertsoni isolated from Egypt are pathogenic strains