Role of anticardiolipin antibodies in vascular complications in patients with chronic renal failure

ABSTRACT

This study included 30 patients with chronic renal failure [15 under regular haemodialysis and 15 under conservative management/or uraemia]. Ten healthy individuals were selected as a control group. Serum IgG anticardiolipin antibodies were determined by ELISA. The results showed that S. IgG anticardiolipin was significantly high in patients with chronic renal failure as compared with the control group [p < 0.01]. Six patients under haemodialysis [40%] and 2 patients under conservative management [13.4%] had positive anticardiolipin antibodies. Patients on haemodialysis with anticardiolipin IgG positivity showed a greater incidence of early thrombosis of anrteriovenous fistula with different varieties of vascular complications. S.IgG anticardiolipin levels in patients with vascular thrombosis were significantly higher than in those without vascular complications [P< 0.001]