Effect of aspirin on serum electrolytes in rabbits

ABSTRACT

Rabbits were injected aspirin doses from [50,100,150,200 and 300] mg/kg body weight intraperitoneally. One hour after injection blood was analyzed for serum electrolytes. Administration of aspirin caused an increase in serum sodium. The rise was significant after administration of 50, 100 and 150 mg/kg body weight aspirin. Administration of 50 mg/kg and 100 mg/kg body weight aspirin caused an increase in serum potassium level. No significant effect was observed on serum calcium level after administration of different doses of aspirin. It is therefore concluded that aspirin when administered in low doses, causes a retention of sodium and potassium in body