How the discrepancy between symptoms and peak expiratory flow rate influences evaluation of asthma severity

ABSTRACT

Recent asthma guidelines recommend the assessment of severity levels based on the most severe symptoms and peak expiratory flow rate [PEFR]. Discrepancies are frequently encountered in the use of these variables in determining the severity levels of asthmatics. The objective of this study was to determine the difference in asthma severity levels as assessed by either symptoms alone or by PEFR alone, as compared with the assessment by the asthma guidelines. Patients and Severity levels that were determined by recent asthma guidelines for 60 asthmatic patients were reassessed, based on symptoms alone and PEFR alone. They were compared for any significant differences to the asthma guidelines. Asthmatics were aged between 15 and 70 [mean 34] years, and 63.8% were females. Severity levels by symptoms alone were different from the guidelines in 27 cases [45%]. Of these, 89% showed a tendency toward higher severity levels. Severity levels by PEFR alone were different in only three cases [5%]. In both comparisons, differences of severity levels were significant [P<0.0001], but assessment by symptoms alone showed more deviation [chi2=162.1] than PEFR alone [chi2=73.1]. The study documented significant discrepancies in asthma severity assessed by symptoms alone and PEFR alone, when compared to the recent asthma guidelines. Severity assessed by symptoms alone showed lower levels, and the use of PEFR tended to categorize some asthmatics into a more severe level