Role of hormonal changes in the pathogenesis of primary female infertility

ABSTRACT

Eighteen female patients with primary infertility [after exclusion of any significant gynecological, cause of infertility] had been studied. Their age ranged from 17 to 40 years with regular periods except 3 patients with 2-3 months amenorrhea. All of them had normal healthy potent husbands with normal semen analysis. All patients were selected to be free endocrine, hepatic as well as metabolic disorders which may interfere with their fertility. They were subjected to estimation [using radioinmunoassay i.e. RIA] of all hormones concerned with fertility. According to the results of their hormonal profile they were classified into 5 groups including 4 patients with hyperprolactinaemia, 2 patients with hypoprolactinaemia and hypogonadotrophinaemia, 4 patients with isolated hypogonadotrophinaemia [2 of them with low progesterone and estradiol serum level], 3 patients with LH hypergonadotrophinaemia and 5 patients with normal hormonal profile. The possible role hormonal changes in the pathogenesis of infertility in these patients has been discussed