Apolipoprotein B and other lipid parameters in coronary atherosclerosis

ABSTRACT

92 patients undergoing coronary angiography, in the cardiology Department of Ain Shams University Hospital. were chosen. According to the results of the angiogram, patients were divided into control group, with normal patent coronary arteries and patient group with atherosclerosis in one or more coronary arteries. To exclude the effect of non lipid risk factors, the paired "t" test was applied to match pairs of patients and controls. Results showed that apo B, TC, LDL-C and B lipoprotein were significantly higher in patient group than in control group; whereas, HDL-C, and a lipoprotein were significantly lower. The ratios of TC/HDL-C and LDL-C/HDL-C were significantly increased in the patient group. To assess the relation of the studied parameters to the severity of the condition, the patient group was further subdivided into a group of moderate atherosclerosis, with lesions in one or two coronary arteries and severe atherosclerosis with lesions in three or more coronary arteries. Comparing both groups together, and to the control group, it was found that apo B was the only parameter, which showed significant difference between both groups. We concluded that apo B had a much better predictive value in relation to CAD risk. It is the only parameter, which is related to the severity of the atherosclerotic process