Effect of sterigmatocystin on histopathological changes in rats kidney and spleen

ABSTRACT

This study investigated the histopathological changes of kidney and spleen tissues in male rats intoxicated with sterigmatocystin. 48 mature albino rats were divided into 6 equal groups. The 1st and 2nd group were administered sterigmatocystin orally in doses of 1.3 and 2.6 mg/60 g BW for 10 days. The animals of the 4th and 5th groups received sterigmatocystin by intraperitoneal in doses of 0.25 and 0.5 mg/60 g BW for 10 days. The 3rd and 6th groups were control groups. Microscopic examination of the oral group revealed cortical hemorrhage, hyaline cast in some of renal tubules and necrosis of the epithelial cells lining many of these tubules in the kidney. These lesions were more prominent in rats treated intraperitoneally and with the increase of the dose of the toxin, while spleen sections of rats showed congestion and hemorrhage. The higher doses of mycotoxin caused atrophy and necrosis of lymphocytes