Comparative study of the effects of antiepileptic drugs [diphenyl hydantoin and sodium valproic acid] on the thyroid function in rabbits

ABSTRACT

The effect of diphenyl hydantoin [DPH] and sodium valproic acid on serum T3, T4 and TSH of the thyroid gland was studied in 21 adult male rabbits receiving DPH and sodium valproic acid for three weeks treatment and was compared to controls. In the DPH treated group, serum T3, and T4 were significantly decreased, while serum TSH was significantly increase. Possible mechanisms underlying this antithyroid effect of DPH are then discussed. In the group of animals received sodium valproic acid, nonsignificant changes in the serum levels of T3,T4, and TSH were observed