Effect of oxaminquine and tartar emetic on the immune response in schistosoma mansoni infection

ABSTRACT

The effect of treatment with oxamniquine and tartar emetic on humoral and cell mediated immunity was studied. The study was done on 30 male patients who were presented with hepatosplenic schistosomiasis [stage II], with active intestinal involvement. After oxamniquine, significant reduction in the IgG immunoglobulin level occurred. Also, improvement of both the suppressed number and function of the T-lymphocyte was observed denoting the reversal of the immunosuppressive state usually met with in schistosomiasis. Tartar emetic led to significant reduction of both IgG and IgE immunoglobulin levels, together with slight improvement in the number and function of T-lymphocytes. All the results were discussed and compared with similar work