Phenytoin-oxamniquine interactions

ABSTRACT

Forty adult male rabbits were divided into four groups Control group, phenytoin [DPH] group, oxamniquine group and a combined group. Fasting blood samples were collected one hour after the last dose using the orbital technique of Riley. Estimation of serum free fatty acids [FFA], total cholesterol, triglycerides, and DPH are done. It was found that combined use of DPH and oxamniquine resulted in a significant increase of serum FFA, total cholesterol and triglyceride, while a nonsignificant increase was noticed in the phenytoin [DPH] group