Comparison of three antimycotic agents in treating recurrent vaginal candidiasis among Egyptian women

ABSTRACT

Three hundred Egyptian women suffering from recurrent vaginal candidiasis were given treatment either in the form of ketoconazole [200 mg oral tablets twice daily for 5 days], clotrimazole [2% vaginal cream once daily for 3 days] or tioconazole [100 mg vaginal tablets once daily for 3 days], and the three treatment regimens were compared. Although the three drugs were highly effective in eradicating infection, the mycological cure rates were better with ketoconazole. Again, ketoconazole was better than the other two agents in nullipara and in cases of severe infection. The acceptability of ketoconazole was much higher than with the other two topical fungicides. It seems that ketoconazole will soon acquire a very important position among the armamentarium against vaginal candidiasis