Glycine and glycyl glycineenriched oral rehydration solutions in the management of infantile diarrhea

ABSTRACT

The study was conducted on 150 male formula-fed uncomplicated cases of acute diarrhea with dehydration. They were randomly classified into 3 groups group A received standard WHO formula [51 cases], group II [49 cases] received ORS containing maltodextrin, glycine and glycyl-glycine while group III [50 cases] received ORS containing maltodextrin in addition to glycine alone. The two new ORS formulations contained the usual thee salts present in the standard ORS with the same concentration. The results showed that there were no significant differences between the thee studied groups as regards the mean number of diarheal motions, the mean daily amounts of diarrheal stools, the mean duration of the diarheal episode, time of first voiding of urine, time needed for initial rehydration, the mean daily amounts of ORS, other plain fluids, milk formula, solid and semisolid foods ingested by the thee groups and mean weight gain. No statistically significant differences were detected between the three studied groups regards the mean serum sodium, potassium and chloride, as well as blood pH and bicarbonate levels recorded levels recorded on admission and after 6, 24 and 48 hours from inclusion in the study and all were within the normal range. It could be concluded that the two study solutions containing maltodextrin together with glycine and glycyl glycine did not prove to have any statistically significant superiority over the standard conventional ORS on the clinical outcome of diarrhea