study of systolic function in insulin dependent diabetic patients in relation to metabolic control and diabetic microangiopathy

ABSTRACT

Left ventricular systolic function was assessed in insulin- dependent diabetic patients in relation to metabolic control and microangiopathy in the absence of cardiac manifestations. According to the degree of control and the presence of microangiopathy, The patients were classified into three groups Group 1 with poor control and with evidence of microangiopathy, group 2 with good control and without microangiopathy and group 3 with poor control and without microangiopathy. Group 1 showed marked reduction in systolic function in the form of decrease in ejection fraction, fractional shortening, prolongation of pre-ejection period [PEP] and PEP/left ventricular ejection index, and increase in septal thickness, which was correlated with the degree of increase in blood pressure. Patients included in group 2 showed no effect in systolic function as compared with control group. Group 3 showed only increase in cardiac output, ejection fraction and functional shortening compared to the control group