Study of the possible effect of some calcium channel blockers on platelet functions and blood fibrinolytic activity in the rabbit

ABSTRACT

Thirty rabbits were used in this study to determine and compare the possible effects of repeated oral daily administration for four weeks of some calcium channel blockers; namely, verapamil [10 mg/kg], perhexiline [10 mg/kg], diltiazem [10 mg/kg], and nifedipine [10 mg/kg] on platelet count and aggregation and on fibrinolytic activity as measured by euglobin clot lysis time [ECLT], plasma platelet factor 4 [antiheparin], concentration and prothrombin, coagulation time. The results indicated that each of verapamil and perhexiline exhibited significant increased tendency to fibrinolysis. On the other hand, diltiazem or nifedipine did not implement such results. Results may indicate that verapamil or perhexiline should be used cautiously in cardiovascular or hematological disorders