Mucosal changes in schistosomal colorectal polyps and colorectal carcinoma

ABSTRACT

This work was carried out on 50 individuals divided into three groups. Group A included 20 volunteers without colorectal disease, group B included 20 patients with schistosomal colorectal polyps and group C included 10 patients with colorectal carcinoma. Histopathological and histochemical studies were done on the endoscopically obtained colorectal specimens from all 50 individuals. Periodic acid Schiff's reagent/Alcian blue stains [PAS/AB], Alcian blue [PHI] and mucicarmine stains were used to identify different types of mucosal mucin with qualitative estimation of the mucin content determined by the degree of reaction. The results showed that control cases have predominantly sulfated mucin with little amount of sialo mucin. Schistosomal polyps showed moderate increase in sialo mucin and transitional zone mucosa in malignant cases proved to have marked increase of sialo mucin