Prostaglandins in thrombotic hemiplegia

ABSTRACT

Prostaglandins may act as local mediators of cellular action in initiating arterial thrombosis, leading to a wide variety of functional changes. This work was carried out to estimate PGE levels in noncomplicated thrombotic hemiplegic patients. There were 15 patients and 20 healthy adults as controls. For each case, clinical examination was carried out together with CT brain, blood cholesterol, triglycerides, total lipids and serum PGE estimated by radioimmunoassay. PGE was shown to be significantly higher in thrombotic hemiplegic group than in the control group, with no statistical significant difference in serum cholesterol triglycerides and total lipids between the two groups. This denotes that PGE acts as a mediator in the thrombotic process in these patients