Infections chez les cancereux granulocytopeniques etudes retrospectives de 59 episodes febriles hospitalises

ABSTRACT

A total of 59 febrile neutropenic episodes were retrospectively recorded at Hotel-Dieu de France hospital between August 1[st] 1991 and December 31[st] 1992. these episodes were recorded in 51 cancer patients. Median neutropenia was less than one week in 50% of the cases. The etiology of these fever was documented in 27 episodes [46%] and in 70% of the cases gram [-] rods were documented. B lactam and aminoglycoside antibiotics were used in 34 episodes at the initial treatment of these patients. Success rate at this initial treatment or with a modification of the antibiotic therapy was recorded in 85% of the patients. Only 15% of the patients failed to this antibiotherapy, 2/3 of them had their disease in progression. The systemic use of amphotericine E in those patients with prolonged febrile neutropenia and the concommitent use of growth factors in a sub-group of patients at high risk could lead to a higher success rate in these patients