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-514C/T polymorphism of hepatic lipase gene among Iranian patients with Coronary Heart disease
Iranian Journal of Public Health. 2012; 41 (1): 59-65
en Inglés | IMEMR | ID: emr-122422
ABSTRACT
The T allele of the hepatic lipase [HL] C-514T polymorphism was previously found to be associated with lower plasma HL activity. Here, we examined the association between this polymorphism and plasma HDL-cholesterol concentrations in patients with coronary arteries stenosis. We studied 342 subjects undergoing coronary angiography in two groups of non CAD [n=146] and CAD [n=196]. -514C->T polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism [PCR-RFLP]. After adjustment for age, smoking and body mass index, HDL-cholesterol concentrations were significantly higher in men with the C/T and T/T genotype than those with the C/C genotype [mean 38.6 and 34.7 respectively P=0.01]. The frequency of T allele in non CAD was 0.136 and 0.226 in female and male respectively and 0.170 and 0.223 for female and male in CAD subjects. There was no difference in T allele frequency in CAD and none CAD groups in male and female [P=0.466 and 0.722 respectively]. -514C-"T of LIPC gene have a positive effect on HDL-C concentration especially in male gender. However, no difference was determined in frequency of T allele between CAD and normal arteries

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Polimorfismo Genético / Polimorfismo de Longitud del Fragmento de Restricción / Reacción en Cadena de la Polimerasa / Enfermedad Coronaria / HDL-Colesterol / Hígado Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Iran. J. Public Health Año: 2012

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Polimorfismo Genético / Polimorfismo de Longitud del Fragmento de Restricción / Reacción en Cadena de la Polimerasa / Enfermedad Coronaria / HDL-Colesterol / Hígado Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Iran. J. Public Health Año: 2012