Iranian Journal of Public Health. 2012; 41 (1): 59-65
en Inglés
| IMEMR
| ID: emr-122422
ABSTRACT
The T allele of the hepatic lipase [HL] C-514T polymorphism was previously found to be associated with lower plasma HL activity. Here, we examined the association between this polymorphism and plasma HDL-cholesterol concentrations in patients with coronary arteries stenosis. We studied 342 subjects undergoing coronary angiography in two groups of non CAD [n=146] and CAD [n=196]. -514C->T polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism [PCR-RFLP]. After adjustment for age, smoking and body mass index, HDL-cholesterol concentrations were significantly higher in men with the C/T and T/T genotype than those with the C/C genotype [mean 38.6 and 34.7 respectively P=0.01]. The frequency of T allele in non CAD was 0.136 and 0.226 in female and male respectively and 0.170 and 0.223 for female and male in CAD subjects. There was no difference in T allele frequency in CAD and none CAD groups in male and female [P=0.466 and 0.722 respectively]. -514C-"T of LIPC gene have a positive effect on HDL-C concentration especially in male gender. However, no difference was determined in frequency of T allele between CAD and normal arteries subjects:
Buscar en Google
Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Polimorfismo Genético
/
Polimorfismo de Longitud del Fragmento de Restricción
/
Reacción en Cadena de la Polimerasa
/
Enfermedad Coronaria
/
HDL-Colesterol
/
Hígado
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Iran. J. Public Health
Año:
2012
Similares
MEDLINE
...
LILACS
LIS