comparison of serum cystatin C and creatinine with glomerular filtration rate in Indian patients with chronic kidney disease

ABSTRACT

There is no literature available on the performance of cystatin C in Chronic Kidney Disease [CKD] patients of Indian population based on age group. Hence, this study is aimed to compare the diagnostic performance of serum cystatin C and creatinine with measured glomerular filtration rate [GFR] and estimated GFR [eGFR] in subjects of Indian origin. The study was carried out at Tiruchirappalli, South India during the period of September 2010 to march 2011. One hundred and six CKD patients [82 males, 24 females] were enrolled and categorized into three groups based on age. The eGFR was calculated using Cockcroft-Gault [CG] and Modification of Diet in Renal Disease [MDRD] formulae. Serum cystatin C was measured with a particle-enhanced nephelometric immunoassay [PENIA] method. GFR was measured using 99mTC - diethylene triamine penta aceticacid [DTPA] renal scan method. Serum cystatin C showed significant correlation with measured GFR in all the three groups [r=-0.9735, r=-0.8975 and r=-0.7994 respectively] than serum creatinine [r=-0.7380, r=- 0.6852 and r=-0.5127 respectively]. Serum cystatin C showed a high correlation with measured GFR in young and older patients with CKD than creatinine. Thus, cystatin C is a good alternative marker to creatinine in CKD patients