Chromosomal study in cases of amenorrhoea

ABSTRACT

Cytogenetic study of 50 cases of primary or secondary amenorrhea was done aiming at the detection of chromosomal abnormalities and sex chromatin patterns. The incidence of abnormal sex chromatin test was 57% in primary amenorrhea and 45% in secondary amenorrhea. The incidence of abnormal karyotyping was 31% in the first group and none in the second group. Also, correlations between the cytogenetic findings with clinical features and laparoscopic findings in these patients were discussed. It was concluded that sex chromatin analysis is a good screening test and should be performed for all cases of amenorrhea. Chromosomal abnormalities constitute a frequent causes of primary amenorrhea