Evaluation of typhidot [IgM] in early and rapid diagnosis of typhoid fever
Professional Medical Journal-Quarterly [The]. 2011; 18 (2): 259-263
en Inglés
| IMEMR
| ID: emr-124012
ABSTRACT
Typhoid fever is widely recognized as a major public health problem in developing countries. A simple, reliable and rapid diagnostic test is needed for clinicians especially in areas where laboratory services are limited. To evaluate sensitivity and specificity of typhidot [IgM], a serological test to identify IgM antibodies against salmonella typhi. This was a prospective study. Northern Institute of Medical Sciences [NIMS] and Ayub Teaching Hospital Abbottabad. 1[st] November 2009 to 31[st] August 2010. A total of 100 patients with clinically suspected typhoid fever were studied and divided into three main groups as A, B and C, with definite typhoid fever, typhoid suspects plus non-typhoidal illnesses and healthy controls respectively. Blood culture and typhidot [IgM] tests were conducted for all subjects included in the study. The validity of typhidot [IgM] test has been evaluated by determining the sensitivity, specificity, positive and negative predictive values. In our study, majority [75%] were males and [25%] females with M to F ratio of 31. The mean age of study group was 26.31 +/- 11.8 [SD] years. Among 100 clinically diagnosed typhoid fever patients, 19 had positive blood culture for S.typhi and 71 were typhidot [IgM] positive. Out of 19 culture positive patients, 18 [94.73%] were true typhidot [IgM] positive, which was also falsely positive in 05 [20.83%] among 24 non- typhoidal febrile controls. None of the healthy controls was positive for typhoid [IgM] test. The sensitivity, specificity, negative and positive predictive values of typhidot [IgM] test using blood culture as gold standard were 94.73%, 90%, 97.72% and 78.26% respectively for patients having typhoid fever. Typhidot [IgM] test is a simple, reliable, rapid and valid diagnostic tool for typhoid fever especially in areas where laboratory services are limited
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Salmonella typhi
/
Pruebas Serológicas
/
Estudios Prospectivos
/
Sensibilidad y Especificidad
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Medios de Cultivo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Professional Med. J.-Q
Año:
2011
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