Relationship between O serotype and virulent genes in Escherichia coli causing urinary tract infections
IJKD-Iranian Journal of Kidney Diseases. 2011; 5 (4): 234-237
en Inglés
| IMEMR
| ID: emr-124533
ABSTRACT
Escherichia coli are the most frequent pathogens in acute urinary infections. They are classified based on various types of O antigen. Escherichia coli strains that cause urinary tract infections possess several genes encoding urovirulent factors. To assay the relation of virulent factors of E coli in acute urinary infections, the serotypes and virulence factor genotypes were determined. We studied 96 E coli isolates from children with acute urinary infections. Four urovirulence determinants were analyzed by DNA colony hybridization, including the genes for type 1 fimbriae [pil], P fimbriae [pap], S fimbriae [sfa], hemolysin [hly], and cytotoxic necrotizing factor 1 [cnfl]. O serotypes were also determined. The most frequently found virulence factor-encoding gene in the E coli strains studied was the gene for type 1 fimbriae [27.4%]. The prevalence of pap, sfa, hly, and cnf1 were higher in serotypes causing pyelonephritis than cystitis. The most common type of O antigen was O1 [12.2%]. There was a significant correlation between serotype and genotype in uropathogenic E coli. The high prevalence of O6 serotypes in children urinary tract infections and the high percentage of virulent genes in serotype O6 suggested a close relation between serotype and genotypes of uropathogen E coli
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Pielonefritis
/
Infecciones Urinarias
/
Virulencia
/
Serotipificación
/
Antígenos O
/
Cistitis
/
Genotipo
Límite:
Humanos
Idioma:
Inglés
Revista:
Iran. J. Kidney Dis.
Año:
2011
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