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Serum paraoxonase 1 activity status in patients with liver disorders
Saudi Journal of Gastroenterology [The]. 2010; 16 (2): 79-83
en Inglés | IMEMR | ID: emr-125513
ABSTRACT
Paraoxonase 1 [PON1] is an esterase, exclusively synthesized by liver. The present study has two

objectives:

to determine the PON1 activity status in various disorders associated with hepatocellular damage and to correlate the changes of PON1 activity with the standard liver function and fasting lipid profile tests in these disorders. The study groups consisted of 95 patients with liver diseases including acute viral hepatitis [14], cirrhosis with portal hypertension [33], leptospirosis [14], sepsis and multi organ failure [15], left ventricular failure [9], and falciparum malaria [10]; and 53 healthy controls. Serum PON1 activity was measured manually using spectrophotometer. Liver function test parameters and fasting lipid profile were performed in clinical chemistry auto analyzer [HITACHI 912]. The serum PON1 activity in patients with acute viral hepatitis and sepsis decreased significantly [P<0.001] and moderately in falciparum malaria [P<0.05]. However, in patients with cirrhosis, leptospirosis and left ventricular patients, its activity did not change significantly. On applying Pearson correlation, serum PON1 activity correlated positively with high-density lipoprotein-cholesterol [HDL-C] in patients with sepsis [r=0.633, P<0.05], left ventricular failure patients [r=0.814, P<0.05] and negatively with acute viral hepatitis patients [r=-0.528, P<0.05]. PON1 activity has decreased significantly in acute viral hepatitis, sepsis with multi organ failure and falciparum malaria patients. Determination of PON1 activity may serve as a useful additional test in assessing these conditions
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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Malaria Falciparum / Sepsis / Hepatitis Viral Humana / Hepatopatías / Insuficiencia Multiorgánica Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Saudi J. Gastroenterol. Año: 2010

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Malaria Falciparum / Sepsis / Hepatitis Viral Humana / Hepatopatías / Insuficiencia Multiorgánica Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Saudi J. Gastroenterol. Año: 2010