[ response of some immune and inflammatory markers of cardiovascular disease in prepubertal overweight boys to a single intense duration of exercise session]

The purpose of this study was to determine the response of some immune and inflammatory markers of cardiovascular disease to a single, short intense duration of exercise, in prepubertal overweight boys exercise. To do this, 13 students 11-14 years-old were selected randomly from among voluntary subjects. In the preliminary session VO2max [26.9 +/- 4.9 ml/kg/min], weight [77.07 +/- 17.33 kg], height [1.65 +/- 0.08], fat percent [31.7 +/- 5.6 percent], body composition, BMI [28.9 +/- 3.5 kg/m2], skeletal age [12.4 +/- 0.9 years] with X-ray, pubertal age with Tanner-stage [T3, T4] was measured and determined familiar illness was done four day before experimental session. In the experimental session, firstly, pre-exercise blood sample collected in fasted state, and then every subject on the ergometer cycle started cycling with 65-70% VO2max for 40 min, post 5 min warming, with 5 min cool down at the end of the program. Immediately post-exercise and recovery blood samples were drawn for measurement by a cell counter employing Isotone Soluble technique, while for hs-CRP and IL_6, we used the immunometric assay Eliza kit. Data were analyzed using the analysis of variance with repeated measures [R-ANOVA] test. The results showed there was a significant relation between different blood samplings. The post hoc [LSD] test that showed neutrophils count and hs-CRP and IL-6 levels one hour after exercise statistically was more than pre-exercise [p=0.001, 0.01, 0.01, respectively] also lymphocyte, monocytes, neutrophils counts and IL-6 level immediately post-exercise [p=0.05, 0.01, 0.004, 0.01, respectively]. Exercise may initiate the response of inflammatory and immune factors in prepubertal obese boys, and increase levels of these factors. This study indicates that a single intense bout of exercise with 65-70% Vo2max can increase subgroups of with blood cells, C-reactive protein and IL-6 in immature obese and overweight children, intense exercise can be activate immune and inflammatory system and increase levels of some of the cited factors