Generalized lymphadenopathy in infancy; a case report

ABSTRACT

Rosai-Dorfman disease [RDD] is a rare disease of histiocytic cells, a cause of benign cervical lymphadenopathy [LAP] and massive generalized lymph node enlargement in children and adults. There are also some reports on involvement of other human body organs with or without LAP. A 7-month-old infant with chief complaint of generalized massive LAP was referred to our center. RDD was diagnosed according to clinical manifestations and confirmed through histopathologic and immunoreactivity study on the obtained sample by cervical lymph node biopsy. RDD is not a malignant illness and lymph node enlargement most often decreases in its size happens without special treatment