Synthesis of biologically active hydrazides and their derivatives
Egyptian Journal of Pharmaceutical Sciences. 1989; 30 (1-4): 133-43
en Inglés
| IMEMR
| ID: emr-12783
ABSTRACT
4-methoxy-[II a] and 4, 7-dimethoxy-6-hydroxybenzofuran-5-carboxylic acid [II b] give the esters [III a-c] upon treatment with diazomethane. IIIa and IIIb form the hydrazides [IV a-b] which on benzoylation in pyridine give the N-benzoyl derivatives [V a-b]. Cyclization of Va, b with phosphoryl chloride leads to the 2-phenyl- 5-substituted-1, 3, 4-oxadiazole derivatives [VI a, b]. Schotten- Baumann benzoylation of IVa affords the O-N-dibenzoyl derivative [VII]. The hydrazide [IVa] condenses with aromatic aldehydes and ketones to form the corresponding hydrazones [VIII a-i]. Compounds IIIa, IVa, VIII b, c, e and i have been found to possess antiaflatoxigenic activity
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Disponibilidad Biológica
Idioma:
Inglés
Revista:
Egypt. J. Pharm. Sci.
Año:
1989
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