Impact of Interleukin-28B gene polymorphism [rs12979860] on Egyptian patients infected with hepatitis C virus genotype-4
EMHJ-Eastern Mediterranean Health Journal. 2013; 19 (Supp. 3): S98-S104
en Inglés
| IMEMR
| ID: emr-128676
ABSTRACT
Single nucleotide polymorphisms [SNPs] in the Interleukin [IL]-28B gene, namely rs12979860, could predict response to pegylated interferon-alpha-ribavirin [PR] therapy in hepatitis C virus genotype 1 [HCV-1]-infected patients. A similar role was investigated in a case-control study conducted on 93 Egyptian patients chronically infected with HCV-4 in comparison to 22 individuals with spontaneous HCV clearance and 70 healthy volunteers. The homozygous C allele genotype [CC] was associated with sustained viral response [SVR] to therapy compared with the homozygous T allele genotype [TT] and the heterozygous genotype [CT]. In the SVR group, the response rate was statistically significantly higher in CC genotypes [58.6%] compared with CT/TT [20.3%]. There was no correlation between SVR patients' genotypes and early response to therapy or HCV baseline viral load. Our findings describe how IL-28B SNP genotyping may guide appropriate selection of HCV-4-infected patients for PR therapy. We underscore IL28B genotyping as a tool that might increase PR cost-benefit in Egypt
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Estudios de Casos y Controles
/
Interleucinas
/
Resultado del Tratamiento
/
Carga Viral
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Polimorfismo de Nucleótido Simple
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Alelos
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Reacción en Cadena en Tiempo Real de la Polimerasa
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Genotipo
Límite:
Femenino
/
Humanos
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Masculino
Idioma:
Inglés
Revista:
East Mediterr Health J.
Año:
2013
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