Comparison of fentanyl, clonidine and tropisetron effect on agitation after sevoflurane anaesthesia in children

ABSTRACT

One hundered ASA physical status I and II children aged 3-6 years were included in this study. After inhalation induction with sevoflurane, patients were randomly assigned to receive either saline [group I, n=25], fentanyl 1 mic/kg IV [group II, n=25] or clondine 3 mic/kg IV [group III, n=25] tropisetron [0.1mg/kg] 10 minutes before discontinuation of anesthetics. There was no significant difference [p>0.05] between the four groups regarding time to eye opening, modified Aldrete recovery scores and post operative complication. The time of first postoperative analgesic dose was significantly shorter in group I compared with other three groups. The incidence of agitation was significantly higher in group I compared with other three groups, the incidence of agitation was 60% in Group I, 30% in Group II, 20% in Group Ill and 25% in Group IV. The dose of fentanyl 1 mic/kg iv or clonidine 3 mic/kg iv or tropisetron [0.1mg/kg]iv that is administered 10 minutes before the termination of anesthesia reduces the postoperative agitation in children with no adverse effects. There was no significant difference [p>0.05] between the four groups regarding age, weight, duration of surgery and discontinuation of anesthetics