possible protective role of Cymbopogon citratus and salvia officinalis against acrylamide toxicity in albino rats

ABSTRACT

Acrylamide [ACR] is an organic chemical compound [polymeric material] that is commonly used in biochemistry and biotechnology labs. It may also occur in our daily life in deep-fried foods; baked goods; tap water and smoking which is also a major ACR producer. In this study, ACR induced a degree of genomic DNA damage, in the form of necrosis of rat spleen, when it was given orally [50 mg/kg b.w.] as a single dose in the first day and as a booster dose in the fifth day of the experiment. The efficacy of[11] mixture of Cymbopogon citratus and Salvia officinalis leaves aqueous extracts was studied. It was administrated to rats in drinking water daily, at 75 and 150 mg/kg b.w. through the 10 days of experiment, as a protective agent against the damage induced by ACR. The DPPH assay was carried out to estimate the antioxidant activity for the plant mixture against ascorbic acid as a standard antioxidant. The results showed an improvement in genomic DNA of rat spleen treated with ACR after treatment with the mixture at low dose but no change was observed at high dose