[Relationship between maternal serum copper level and birth weight neonate]

ABSTRACT

Low birth weight [LBW] is a major public health problem. LBW is associated with increased neonatal morbidity and mortality. There is no consensus in the literature as to whether maternal copper nutrition is associated with pregnancy outcome or fetal growth. This case-control study was carried out at Alavi Hospital in Ardabil between August 2008 and August 2009. 56 women who had delivered low-birth- weight infants [<2500gr] were taken as the case group, and from the mothers who had delivered normal birth weight infants [>/= 2500gr], 56 were selected at random as the control group. Venous blood samples were obtained from the mothers. Serum zinc level was determined by the Atomic Absorption Spectrophotometer method. Mean of birth weight in infants, maternal age, body mass index in mothers and socioeconomic or demographic factors did not differ between cases and control groups. Maternal copper concentration [micro g/dl] differed between Cases and Controls; 231.75 +/- 38.12 micro g/dl vs. 204.42 +/- 31.30 micro g/dl respectively. There is a significant difference [p<0.001] in the serum copper concentration between the two groups. There is a negative relation between low infant birth weight and maternal copper concentration