Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine
Pakistan Journal of Pharmaceutical Sciences. 2011; 24 (3): 251-254
en Inglés
| IMEMR
| ID: emr-129849
ABSTRACT
Long term intake of coffee is known to produce anxiety and suppression of appetite. 5- hydroxytryptamine [5-HT] acting via 5-HT-2C receptors elicits anorexia and anxiety. The present study is design to monitor metachloro phenyl piperazine [m-CPP] at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine [a component of coffee and tea] or theophylline [a component of tea] as a sole source of water. We found that hypophagic and hypolocomotive effects of m-CPP were attenuated in theophylline but not in caffeine treated animals suggesting that long term intake of theophylline may, attenuate anorexiogenic and anxiogenic effects of 5-HT. A possible role of 5-HT-2C receptors in the modulation of anxiety and appetite in people drinking coffee or tea discussed
Buscar en Google
Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Piperazinas
/
Teofilina
/
Cafeína
/
Agonistas de Receptores de Serotonina
/
Ratas Wistar
/
Interacciones Farmacológicas
/
Actividad Motora
Límite:
Animales
Idioma:
Inglés
Revista:
Pak. J. Pharm. Sci.
Año:
2011
Similares
MEDLINE
...
LILACS
LIS