Induced hypotension for functional endoscopic sinus surgery: a comparative study of dexmedetomidine versus esmolol

ABSTRACT

A comparative study to evaluate the efficacy of dexmedetomidine as a hypotensive agent in comparison to esmolol in Functional Endoscopic Sinus Surgery [FESS]. Forty patients ASA I or II scheduled for FESS were equally randomly assigned to receive either dexmedetomidine 1 microg/Kg over 10 min before induction of anesthesia followed by 0.4-0.8 microg/Kg/h infusion during maintenance [DEX group], or esmolol, loading dose 1mg/kg was infused over one min followed by 0.4-0.8 mg/kg/h infusion during maintenance [E group] to maintain mean arterial blood pressure [MAP] between [55-65 mmHg]. General anesthesia was maintained with sevoflurane 2%-4%. The surgical field was assessed using Average Category Scale and average blood loss was calculated. Hemodynamic variables [MAP and HR]; arterial blood gas analysis; plasma cortisol level; intraoperative fentanyl consumption; Emergence time and total recovery from anesthesia [Aldrete score >/= 9] were recorded. Sedation score was determined at 15, 30, 60 min after tracheal extubation and time to first analgesic request was recorded. Both DEX group and E group reached the desired MAP [55-65 mmHg] with no intergroup differences in MAP or HR. The for the quality of the surgical filed in the range of MAP [55-65 mmHg] were <=2 with no significant differences between group scores during hypotensive period. Mean intraoperative fentanyl consumption was significantly lower in DEX group than E group. Cortisol level showed no significant changes between or within groups. No significant changes were observed in arterial blood gases. Emergence time and time to achieve Aldrete score >/= 9 were significantly lower in E group compared with DEX group. The sedation score were significantly lower in E group compared with DEX group at 15 and 30 minutes postoperatively. Time to first analgesic request was significantly longer in DEX group. Both dexmedetomidine or esmolol with sevoflurane are safe agents for controlled hypotension and are effective in providing ideal surgical field during FESS. Compared with esmolol, dexmedetomidine offers the advantage of inherent analgesic, sedative and anesthetic sparing effect