Thyroid hormone replacement one day before [131]I therapy in patients with well-differentiated thyroid cancer
Asia Oceania Journal of Nuclear Medicine and Biology. 2013; 1 (1): 20-26
en Inglés
| IMEMR
| ID: emr-130672
ABSTRACT
The current study aimed to determine the efficacy of radioiodine-131 [131I] ablation therapy with thyroid hormone replacement one day before [131]I administration in patients with well-differentiated thyroid cancer [DTC]. This retrospective study included 29 patients who underwent [131]I therapies twice for DTC during 6-12 months. Since all the patients obviously had residual lesions by their serum thymoglobulin levels or their scintigrams at the first therapies, they underwent the second [131]I therapies without diagnostic scintigraphy after the first therapies. After confirming the sufficient elevation of TSH concentration, thyroid hormone replacement was resumed one day before [131]I administration [3.7-7.4GBq]. The ablation rate of thyroid remnant at the first [131]I therapy was evaluated by comparing [131]I post-therapeutic images of the two treatments. Three patients were administrated thyroid hormone after [131]I therapy because of insufficient TSH concentration under thyroid hormone withdrawal. In the remaining 26 patients, 41 thyroid remnant accumulations were detected in all 26 patients at the first [131]I therapy. Based on the second [131]I post-therapeutic images, successful ablation was confirmed in 24 of 26 patients [92.3%] and 38 of 41 sites [92.7%], which was comparable with historically reported ablation rates. Thyroid hormone replacement one day before [131]I therapy could provide a sufficiently high ablation rate in patients with DTC
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Hormonas Tiroideas
/
Estudios Retrospectivos
/
Terapia de Reemplazo de Hormonas
/
Radioisótopos de Yodo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Asia Oceania J. Nucl. Med. Biol.
Año:
2013
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