Pentoxifylline decreases serum level of adhesion molecules in atherosclerosis patients
IBJ-Iranian Biomedical Journal. 2014; 18 (1): 23-27
en Inglés
| IMEMR
| ID: emr-130680
ABSTRACT
Inflammation is involved in development, progression, and complications of atherosclerotic disease. Clinical studies have indicated that the level of monocyte chemoattractant protein 1 [MCP-1], IL-18, and adhesion molecules correlates with the severity of atherosclerosis and can predict future cardiovascular events. Experimental studies have shown pentoxifylline [PTX] reduces these factors in animal models. The purpose of the present pilot study was to evaluate effect of PTX on a group of inflammatory biomarkers in patients with coronary artery disease [CAD]. Forty patients with angiographically documented CAD, who fulfilled inclusion and exclusion criteria, were entered in the double-blind, randomized, pilot clinical study. The patients were randomly given PTX [400 mg three times daily] or placebo [3 tab/day] for 2 months. Serum concentrations of MCP-1, IL-18, intercellular adhesion Molecule 1 [ICAM-1], and vascular cell adhesion molecule 1 [VCAM-1] were measured before and at the end of intervention by enzyme-linked immunosorbant assay. Our study showed that the serum levels of ICAM-1 and VCAM-1 was decreased in the study population after two-month treatment [P<0.05]. Based on the results of our pilot study, administration of PTX in CAD patients significantly decreases adhesion molecules levels
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Biomarcadores
/
Moléculas de Adhesión Celular
/
Molécula 1 de Adhesión Intercelular
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Molécula 1 de Adhesión Celular Vascular
/
Aterosclerosis
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Iran. Biomed. J.
Año:
2014
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