Campylobacter pyloridis in gastric carcinoma

ABSTRACT

25 radical gastrectomy specimens and 4 autopsy control stomachs were selected, consisting of 7 well differentiated, 6 moderately differentiated adenocarcinomas and 12 poorly differentiated carcinomas [including anaplastic, signet ring and poorly differentiated adenocarcinomas]. H and E and PAS stained slides from the tumour and the adjacent tumour free mucosa were screened for Campylobacter pyloridis [C. pyloridis]. 9 out of the 25 neoplasm specimens [36 percent], demonstrated the organism which was prevalent in the more differentiated carcinomas. The incidence of C pyloridis in the adjacent mucosa presenting with active gastritis was [56.2 percent] and nearly half the positive tumours were also associated with C. pyloridis positive adjacent mucosa. The controls and the gastritis free mucosa around the neoplasma did not show the organisms