Pharmacokinetics of cefazolin and chloramphenicol in protein-energy malnuirition

ABSTRACT

The antibacterial levels of cefazolin and chloramphenicol-Chloramphenicol were assayed in the serum by a microbiological method using Sarcina lutea as the test organism. Twenty infants and children suffering from protein-energy malutrition [PEM] compared to normal controls of the same age and sex were the subject of this study. All children were studied on two separate occasions with a seven to ten days interval between the two studies. The bioavailabitity of chloramphenicol for parenteral route was found to be significantly higher in malnourishd infants and children compared to normal controls, while with cefazolin no variation from normal was noticed. Concomitant higher levels of chioram were assayed in the serum by a microbiological method using Sarcina lutea as the test organism