Synthesis and study of cytotoxic potency of novel coumarin derivatives against breast cancer cell line
Egyptian Journal of Chemistry. 2009; 52 (3): 431-450
en Inglés
| IMEMR
| ID: emr-135693
ABSTRACT
New series of coumarin derivatives was synthesized and evaluated as antitumor agents against breast cancer in human cell line [MCF 7]. The key compound 8-acetyl-7-hydroxy-4-methyl coumarin [1] was synthesized and condensed with phenyl hydrazine to form the hydrazone derivative 2. Also, 1 condensed with different alkylating agents to give the corresponding sulphonyl derivatives 3a, b which further condensed with 2,4-dinitrophenyihydrazine to give the corresponding hydrazones 4a,b. One pot reaction of 5 with different aldehydes, ethylcyanoacetate and ammoniumacetate gave pyridone derivatives 6a-e. Also. compound 5 condensed with different aldehydes then cyclized to give the pyrazoline derivatives 9a,b and 10a,b. While, on condensation of 5 with thiosemicarbazide derivatives followed by cyclization the resulting product, gave the oxathiazoline 12 and thiazolidine 13. Some of these newly synthesized compounds showed noderate activity against breast carcinoma cell line[MCF7] in human
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Piridonas
/
Neoplasias de la Mama
/
Cumarinas
/
Citotoxinas
Idioma:
Inglés
Revista:
Egypt. J. Chem.
Año:
2009
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